Robust, high yield, stable cell lines to underpin your GMP manufacturing campaign

Cell Line Development

Fusion Antibodies has experience with a range of mammalian cell lines to offer confidence and flexibility in supporting your clinical development. We provide rapid development of well-characterized mammalian cell lines with a good clinical record.

Begin with the end in mind.

Key
Features

CHO-K1, CHO-GS knockout and CHO-S systems available
Up to 8g/L
FDA/EMA standards, TSE/BSE testing with fully traceable documentation
Royalty free platforms
Flexible commercial licensing
Robust and scalable system
Proven stability over 120 generation cycles
Early-stage manufacturability assessment
Flexible tech-transfer to the CMO of your choice

Stable Pools and Research Cell Lines

Flexible, adaptable development options provide a customized pathway to the clinic. For smaller projects such as preclinical in vivo efficacy studies, PK/PD studies or protein characterization studies, expression from stable pools is the perfect solution for the supply of purified protein in 1mg to 1g.

For maximum flexibility, we can offer the option to develop multiple cell lines in parallel to the minipool stage. Initial expression and stability data can then be used to determine the best expression system for your molecule before progressing to a GMP-ready Research Cell Bank (RCB).

Manufacturing
Cell Lines

We can deliver a monoclonal RCB in approximately four months using both standard and fast-tracked protocols. We deliver a robust manufacturing cell line, high throughput screening of clones, detailed characterization in batch cultures, provision of multiple cell banks and flexible tech transfer to the CMO of your choice. Extended stability studies give you confidence ahead of your GMP manufacturing campaign, and robust documentation ensures regulatory compliance.

We have long-standing relationships with large-scale GMP manufacturing partners and regulatory advisers to facilitate seamless transfer to the clinic.

Why Fusion Antibodies?

Reduced cost, rapid timelines, increased flexibility and unrivalled customer service
Open and flexible approach to business and project planning
Proven, reliable biologics manufacturing services (antibodies and non-antibody proteins)
Regulatory support
State-of-the-art facilities with complete project isolation
Full suite of supporting services including early stage developability assessment, protein engineering, affinity maturation and humanization.

Additional Reading

Expert Insights

Overcoming obstacles on the path to the clinic

Finding a high-affinity antibody that binds to your target is only the first step. Not every antibody has what it takes to become a licensed medicine.

Expert Insights

Starting your journey into manufacturing – choosing a cell line development provider

One of the biggest decisions which any company developing biological medicines makes is to move forward to the manufacture of their product.

Optimize your antibody to be the best

Find out more about partnering with Fusion Antibodies or contact us to start a project

Get Started

Fusion Antibodies PLC, Springbank Industrial Estate, 1 Springbank Rd, Dunmurry, Belfast BT17 0QL

Robust, high yield, stable cell lines to underpin your GMP manufacturing campaign

Cell Line Development

Key Features

Stable Pools and Research Cell Lines

Manufacturing Cell Lines

Why Fusion Antibodies?

Additional Reading

Contact us about Cell Line Development

Optimize your antibody to be the best

JOURNEY WITH US

ABOUT US

CONTACT US

Key
Features

Manufacturing
Cell Lines