Ideal drug or dead-end molecule?

Are you ready to move to transient protein expression? On the surface, an antibody molecule can look like an ideal candidate but what if you looked a little closer?

In-depth characterization is a vital stage in scaling up your molecule for transient protein expression and ultimately stable cell line development.

Spending time on a transient protein expression pilot program can help you rule out dead-end molecules and avoid nasty surprises at a later stage.

5 top tips for a transient protein expression pilot

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Think you know your molecule?

Having the ability to distinguish an ideal drug candidate from a dead-end molecule at this stage is an absolute must for a successful drug developer.

In this example, the presence of multimers and aggregates, only identified by a more thorough analysis, skew the affinity results and mask a low quality preparation of antibody.

Deep analysis of function, purity and protein quality is therefore vital.

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About Fusion Antibodies

We are world leaders in antibody development services specializing in the discovery, engineering and supply of pre-clinical biologics to clinical Cell Line Development.

Fusion offers flexibility and agility while delivering clinical candidates focusing on developability, manufacturability and function.

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Additional Reading

Expert Insights

Piloting successful transient protein expression

Waving goodbye to antibody engineering and moving your lead candidates into transient protein expression is a big milestone in therapeutic antibody development. Wise developers budget a few weeks into their timelines to invest in a small-scale pilot project before scaling up.

Expert Insights

Harnessing the rabbit antibody repertoire

Rabbit derived monoclonal antibodies have become important starting points for therapeutic molecules. However, humanization of these antibodies can present challenges as traditional techniques have been concomitant with affinity loss and other issues.

Expert Insights

Bispecifics – Expanding the potential of immunotherapies

With a quality by design approach, we employ our in silico and protein engineering expertise to design and optimize an engineering program ideal for an antibody candidate, shaped with the endpoint in mind.

Optimize your antibody to be the best

Find out more about partnering with Fusion Antibodies or contact us to start a project

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Fusion Antibodies PLC, Springbank Industrial Estate, 1 Springbank Rd, Dunmurry, Belfast BT17 0QL

Ideal drug or dead-end molecule?

5 top tips for a transient protein expression pilot

Think you know your molecule?

About Fusion Antibodies

Additional Reading

Optimize your antibody to be the best

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